The Gastric Mucous Barrier

The oesophagus lined with gastric mucous membrane.

Peptic oesophagitis and peptic ulceration of the squamous epithelium of the oesophagus are secondary to regurgitation of digestive juices, are most commonly found in those patients where the competence ofthe cardia has been lost through herniation of the stomach into the mediastinum, and have been aptly named by Barrett (1950) " reflux oesophagitis." In the past there has been some discussion a...

Effect of gastric secretory inhibitors on the gastric mucosal barrier.

The effects of the synthetic prostaglandin 16, 16 dimethyl-E2 methyl ester (16-diMe-PGE2) and the histamine H2-receptor antagonist metiamide on the gastric mucosal barrier have been studied using the Heidenhain pouch dog model. The 16-diMe-PGE2 caused significant change in the ionic permeability of the mucosa when instilled into the pouch in a concentration of 300 mug/20 ml. Intravenous adminis...

Growth cycle of Helicobacter pylori in gastric mucous layer.

Helicobacter pylori bacterium is characterized by its strong urease activity. Our studies on the role of H. pylori urease revealed; (i) it is essential for colonization, (ii) exogenous urea is required for acid resistance, (iii) the bacteria have the ability to move toward urea and sodium bicarbonate, (iv) urea hydrolysis accelerates chemotactic locomotion, and (v) decay of urease mRNA to accom...

Gastric surfactant and the hydrophobic mucosal barrier.

Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surface mucous gel layer.

BACKGROUND AND AIMS Helicobacter pylori locate not only on the apical surface of surface mucous cells but also in the mucous gel layer covering the gastric mucosa. The present study was undertaken to observe the mucous gel layer itself and any H pylori in this layer at the electron microscopic level, and to determine whether H pylori proliferate in this layer. METHODS We examined resected hum...